Alcoholic Neuropathy StatPearls NCBI Bookshelf

Caspases, or cysteine-aspartic acid proteases, are a family of cysteine proteases, which play an essential role in apoptosis (programmed cell death), necrosis and inflammation. Translocation of NFkβ to the nucleus has been reported to result in activation of the endogenous proteolytic enzyme system caspases [69]. Joseph & Levine [71] suggested that activity in signaling pathways…

Symptoms & Treatment for Alcoholic Neuropathy

In addition, patients with chronic alcoholism tend to consume smaller amounts of essential nutrients and vitamins and/or exhibit impaired gastrointestinal absorption of these nutrients secondary to the direct effects of alcohol. These relationships make chronic alcoholism a risk factor for thiamine deficiency. In addition to thiamine deficiency, recent studies indicate a direct neurotoxic effect of…

Abstinence Violation Effect AVE What It Is & Relapse Prevention Strategies

In sum, the current body of literature reflects multiple well-studied nonabstinence approaches for treating AUD and exceedingly little research testing nonabstinence treatments for drug use problems, representing a notable gap in the literature. The most promising pharmacogenetic evidence in alcohol interventions concerns the OPRM1 A118G polymorphism as a moderator of clinical response to naltrexone (NTX).…

Understanding the Abstinence Violation Effect and its Role in Relapse Prevention Treatment in SearchWorks catalog

Harm reduction therapy has also been applied in group format, mirroring the approach and components of individual harm reduction psychotherapy but with added focus on building social support and receiving feedback and advice from peers (Little, 2006; Little & Franskoviak, 2010). These groups tend to include individuals who use a range of substances and who…

Relapse prevention PMC

Further, a randomized trial of olanzapine led to significantly improved drinking outcomes in DRD4 L but not DRD4 S individuals [100]. In conclusion, the abstinence violation effect is a psychological effect that impacts those in recovery, as well as those who are focused on making more positive behavioral choices in their lives. By reframing lapses…

Relapse prevention for addictive behaviors PMC

Based on activation patterns in several cortical regions they were able to correctly identify 17 of 18 participants who relapsed and 20 of 22 who did not. Functional imaging is increasingly being incorporated in treatment outcome studies (e.g., [133]) and there are increasing efforts to use imaging approaches to predict relapse [134]. While the overall…